Novel targeted therapies of T cell lymphomas
نویسندگان
چکیده
منابع مشابه
Targeted therapies in B-cell non-Hodgkin lymphomas
Non-Hodgkin lymphomas (NHLs) are increasing in incidence and will be diagnosed in more than 55,000 individuals this year alone [1,2]. The 13 most frequent clinical classes recognized in the lymphoma classification include diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), small lymphocytic lymphoma (SLL) mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL), marginal B-cel...
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Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy characterized by short median survival despite intensive therapies. The clinical behavior of MCL may be due to the complex pathophysiology of the disease which includes its genetic hallmark, the chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1, alteration in the DNA damage response, and constitutive ac...
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Peripheral T-cell lymphomas (PTCL) are an uncommon, heterogeneous group of non-Hodgkin lymphomas that carry a much poorer prognosis than their more common B-cell counterparts. The most commonly used treatment is CHOP or its variations. However, while the results with CHOP are inadequate, there is little compelling data to suggest a preferred alternate strategy. Many of these alternate strategie...
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Although the precise pathogenesis of rheumatoid arthritis (RA) remains unclear, many cell populations, including monocytes, macrophages, endothelial cells, fibroblasts and B cells, participate in the inflammatory process. Ongoing research continues to evaluate the critical roles played by B cells in sustaining the chronic inflammatory process of RA. These findings have contributed to the develo...
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ژورنال
عنوان ژورنال: Journal of Hematology & Oncology
سال: 2020
ISSN: 1756-8722
DOI: 10.1186/s13045-020-01006-w